Annet писал(а):
Sanseviera, а по кветиапину есть что-нибудь?
Есть на е-лактанции, там в конце ссылки на исследования.
http://e-lactancia.org/producto/1302Quetiapine
Last update: Nov. 5, 2014
Breastfeeding risk
Very low risk
Compatible.
Not risky for breastfeeding or infant.
Comment
Excreted into breast milk in non-significant amount with no problems among breastfed infants whose mothers were treated with this medication.
Galactorrhea may be seen even without increase of prolactin secretion.
Tradenames
Main tradenames from several countries containing Quetiapine in its composition:
Seroquel™
Group
Quetiapine belongs to this group or family:
Anti-psychotics Diazepines, oxazepines and thiazepines
Pharmacokinetics
Variable Value Units
Molecular weight 384 daltons
Proteins Binding 83 %
Distribution Volume 10 l/Kg
Milk/Plasma ratio 0,3 -
Time to max, Tmax 1,5 hours
Elimination half-life, T1/2 7 hours
Bioavailability 10 %
Theoretical Dose 0,01 - 0,1 mg/Kg/d
Relative Dose 0,1 - 0,43 %
References
List of 10 references
Suttajit S, Srisurapanont M, Xia J, Suttajit S, Maneeton B, Maneeton N. Quetiapine versus typical antipsychotic medications for schizophrenia. Cochrane Database Syst Rev. 2013 Abstract Full text (link to original source)
Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. \ Pediatr Clin North Am. 2013 Feb;60(1):275-94. 2013 Abstract
Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Abstract Full text (link to original source)
Mushtaq S, Khan S, Patel H. Quetiapine-induced galactorrhea with normal prolactin level in an adult female patient. Prim Care Companion CNS Disord. 2012 Abstract Full text (in our servers)
Juruena MF, de Sena EP, de Oliveira IR. Safety and tolerability of antipsychotics: focus on amisulpride. Drug Healthc Patient Saf. 2010 Abstract Full text (link to original source) Full text (in our servers)
Newport DJ, Ritchie JC, Knight BT, Glover BA, Zach EB, Stowe ZN. Venlafaxine in human breast milk and nursing infant plasma: determination of exposure. J Clin Psychiatry. 2009 Abstract
Rampono J, Kristensen JH, Ilett KF, Hackett LP, Kohan R. Quetiapine and breast feeding. Ann Pharmacother. 2007 Abstract Full text (link to original source)
Gentile S. Quetiapine-fluvoxamine combination during pregnancy and while breastfeeding. Arch Womens Ment Health. 2006 Abstract Full text (link to original source)
Misri S, Corral M, Wardrop AA, Kendrick K. Quetiapine augmentation in lactation: a series of case reports. J Clin Psychopharmacol. 2006 Abstract
Lee A, Giesbrecht E, Dunn E, Ito S. Excretion of quetiapine in breast milk. Am J Psychiatry. 2004 Abstract Full text (in our servers)